Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.
Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells here (pAPC).Peptide-MHC complexes are produced by two spatially distinct pathways during virus infection.Endogenous antigens synthesized within virus-infected pAPC are presented via the direct-pres